Treating De Novo Metastatic Castration-Sensitive Prostate Cancer With Visceral Metastases: An Evolving Issue
نویسندگان
چکیده
Visceral metastasis is widely considered a prognostic factor for overall survival of men with metastatic castration-sensitive prostate cancer (mCSPC) and has been historically managed androgen deprivation therapy (ADT). More recently, this therapeutic scenario enriched by the possibility to integrate ADT chemotherapy or novel androgen-signaling–targeted inhibitors. In order define effect chemotherapy/androgen-signaling–targeted inhibitors plus ADT, we performed pooled analysis on patients mCSPC visceral metastases, revealing that was significantly improved in without (hazard ratio, 0.64; 95% confidence interval, 0.56-0.74; P < .01) compared metastases 0.68; 0.51-0.91; .01). Although several limitations do not allow us draw definitive conclusions, our confirms efficacy combination as well. absence specific randomized controlled trials, symptoms, toxicity, cost, patient preference, clinical experience should guide decision add receptor–targeted from mCSPC.
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ژورنال
عنوان ژورنال: Clinical Genitourinary Cancer
سال: 2021
ISSN: ['1558-7673', '1938-0682']
DOI: https://doi.org/10.1016/j.clgc.2020.06.001